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A major limitation in evaluating the respiratory effects of e-cigarettes is that the majority of studies have been conducted in individuals with a prior history of combustible cigarette smoking, which introduces confounding and complicates the interpretation of findings, particularly in cross-sectional designs that preclude the ability to infer causality

Pharmacotherapy includes nicotine replacement therapy (usually a combination of nicotine patches and one or more short-acting forms such as gum, lozenges, spray or vaporiser), varenicline or bupropion (depending on country)

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